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Vital muscles such as those powering the heart and lungs are also eventually affected

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Vital muscles, such as those powering the heart and lungs, are also eventually affected. It contains the information for making the protein dystrophin, which is vital for muscle function. Without it, all the muscles of the body, usually starting with those in the legs, gradually wither and die, to be replaced by fat. Great things were expected of Newport-Gwent Dragons, but still they went down to Perpignan.In short, the overall performance of the Welsh clubs has been just as disappointing as it has been in the Heineken group matches of previous years Only the Scottish clubs have been more of a pushover.

"I definitely want to stay at City because I have really improved as a player here. It is nice to be linked with top clubs but the important thing is this one and what we do. I really enjoy it at Manchester City and I want to keep that going."Keegan should receive some more good news tomorrow when the former England Under-21 keeper Nicky Weaver makes his long awaited return in a reserve game against Blackburn. Weaver has missed virtually three full seasons after a succession of knee injuries, which eventually required pioneering cartilage transplant surgery earlier this year.. Not content with battling against relegation from the Zurich Premiership, bottom-of-the-table Northampton have now taken fighting among themselves. "This is not a cure because you will have to keep repeating the treatment, but it may slow the loss of muscle."DMD is caused by a mutation in the dystrophin gene that, nobody knows why, is huge - the largest in the body. "We have shown in mice that it is possible to patch up the gene so that it starts working again," says Professor Francesco Muntoni of Imperial College in London.

"The consultant's attitude was: 'This child will be dead by 16 or 20. You had better get on with your lives and make the best of it.'"That was four years ago, and since then the situation for parents faced with the shock of a diagnosis of DMD has been transformed, thanks in no small part to the energy and determination of the Fitzpatricks. From their home in Rotherham, they have run workshops and set up internet message boards where people can ask for help and support each other, as well as founding an organisation called Parent Project UK, dedicated to finding a viable treatment and cure.Already, a treatment to repair the faulty gene is due to be put through a human clinical trial next year. "Basically, you feel as if your world has come to an end." The consultant said nothing to the two parents. Instead, he passed a note across the table that contained three devastating lines: Muscle-wasting disease Wheelchair by nine Death by 16 "That was all it said," recalls Gail Fitzpatrick. Instead, his problems with walking were due to a genetic, muscle-wasting disorder known as Duchenne muscular dystrophy (DMD), for which there is no cure.

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